The Orthopaedic Research Laboratory (ORL) of Radboudumc starts a new project with ATRO Medical: 3D-Printed PCU meniscus Prosthesis (3PPP). 3PPP combines the latest developments in sports medicine with the strength of AI. The durable meniscus prosthesis of ATRO Medical will be designed in 3D based on artificial intelligence, developed by the Orthopaedic Research Lab. Thanks to this technology, a scan of the healthy meniscus in one leg can be used to create a meniscus solution for the affected leg. In this way, the side with a lacking meniscus causing severe knee pain can receive a new shock absorber, molded to the individual patient.
Each year, more than 1.2 million American and European patients lose their meniscus due to injury. Many incidents result from sports activities, such as soccer and other contact sports. More than 200,000 patients are left with such a painful knee that they can no longer play sports and sometimes even have to stop working. Only 5 percent of these patients benefit from surgery. The pain of the remaining patients can sometimes be relieved temporarily, but no permanent solution is available for them.
Anatomy of individual patient measures
A meniscal prosthesis can restore shock absorption in the knee to relieve pain and increase the patient's quality of life. ATRO Medical is currently clinically evaluating a standard implant, which is available in five sizes. The next step is a more personalized solution, based on the patient's own anatomy. With the latest developments in imaging techniques, artificial intelligence and 3D printing, this option is actually becoming possible.
Proof of principle
The 3PPP project should provide evidence that AI-based meniscus modeling of MRI images, including the development of the surgical procedure and tools needed, does indeed work (proof of principle). All aspects will be verified in the testing facilities of the Orthopaedic Research Lab of the Department of Orthopedics at the Radboudumc, bringing this technology close to clinical introduction. Maarten van der Zanden, CIO of ATRO Medical: "We are very pleased with the expansion of our collaboration and with the opportunity to discover how AI can be used for knee patients with meniscus problems."
A study of ATRO Medical's first artificial meniscus is currently underway in the Netherlands with 14 patients in three clinics. 3PPP is a two-year SME project, co-funded by Health~Holland, Top Sector Life Sciences & Health, to stimulate public-private partnerships.
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Patients
Artimis®: the new name for the world’s first artificial meniscus
Patients
As the first company worldwide, ATRO Medical will start a clinical trial on a lateral artificial meniscus. For the first time ever, an absent meniscus in the outer part of the knee will be replaced by an artificial meniscus, the Artimis® Meniscus Prosthesis. The study will be conducted at the Radboud University Medical Center in Nijmegen.
Patients
This clinical study is initiated in October 2021 to enroll 14 patients at select medical centers in the Netherlands. The study is full and can no longer accept new participants. The clinical study is approved by the Dutch government (Dutch Health and Youth Care Inspectorate) and Medical Research Ethics Committee.
Professionals
The Orthopaedic Research Laboratory (ORL) of Radboudumc starts a new project with ATRO Medical: 3D-Printed PCU meniscus Prosthesis (3PPP). 3PPP combines the latest developments in sports medicine with the strength of AI. The durable meniscus prosthesis of ATRO Medical will be designed in 3D based on artificial intelligence, developed by the Orthopaedic Research Lab. Thanks to this technology, a scan of the healthy meniscus in one leg can be used to create a meniscus solution for the affected leg. In this way, the side with a lacking meniscus causing severe knee pain can receive a new shock absorber, molded to the individual patient.
Patients
Dutch medical innovations are rarely granted the Breakthrough Designation by the FDA. Startup ATRO Medical from Nijmegen is the new kid on the block in orthopedics. This week their Trammpolin® meniscus prosthesis (nowadays known as Artimis®), designed to treat chronic knee pain, received the Breakthrough Device Designation from the FDA. The designation demonstrates the innovation potential of this implant and expedites US market access by receiving a priority treatment at the FDA.
Professionals
An international consortium led by the Dutch med-tech startup ATRO Medical receives over € 800,000 EUROSTARS funding to address an unmet need for Knee Osteoarthritis patients. These patients often suffer from cartilage degradation related to a dysfunctional meniscus. Based on previous research, the consortium will develop a durable meniscus prosthesis for the outer knee compartment to relief pain and restore mobility. This would change the life of thousands of osteoarthritis patients.
Professionals
Yess!! ATRO Medical has been named an Awardee in the Veterans Lead QuickFire Challenge organized by Johnson & Johnson Innovation!
Patients
Orthopedic startup ATRO Medical enters a partnership together with the Dutch Arthritis Society for further development of the artificial meniscus. The Dutch startup works on a meniscus prosthesis for people with knee arthritis. The Dutch Arthritis Society supports these developments and shares its experience as patient expert in the field of arthritis.
Professionals
The European Commission grants € 2.5 million to ATRO Medical for the accelerated development of their artificial meniscus. The Dutch startup works on the first anatomical meniscus prostheses for patients with chronic knee pain. Their ground-breaking innovation continues to attract international attention, paving the way towards full-scale healthcare implementation.
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